Observations on the Structural Formula for Mycophenolic Acid by J. H. Birkinshaw, H. Raistrick
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چکیده
Alsberg & Black (1913) first isolated and named mycophenolic acid, C17H200,6, from culture filtrates of PeniciUlium stoloniferum Thom. The acid was next reported by Clutterbuck, Oxford, Raistrick & Smith (1932) as a metabolic product of twelve species or strains in the P. brevi-compactum series, a series to which P. stoloniferum belongs. Clutterbuck & Raistrick (1933), as the result ofan extensive chemical examaination of mycophenolic acid, advanced a tentative partial structural formula for it which was modified and amplified by Birkinshaw, Bracken, Morgan & Raistrick (1948). These workers suggested structures (I) or (II) as most clearly illustrating the known properties and chemical behaviour ofmycophenolic acid, and preferred (I) to (II). Further work on this subject which supports (I) is reported in the present communication.
منابع مشابه
Antibacterial activity of the triterpenoid acid (polyporenic acid C) and of ungulinic acid, metabolic products of Polyporus benzoinus (Wahl.) Fr.
Asano, M. & Kameda, Y. (1941). J. pharm. Soc. Japan, 61, 57. Birkinshaw, J. H., Bracken, A. & Findlay, W. P. K. (1944). Biochem. J. 38,131. Birkinshaw, J. H. & Findlay, W. P. K. (1940). Biochem. J. 34, 82. Birkinshaw, J. H. & Morgan, E. N. (1950). Biochem. J. 47, 55. Birkinshaw, J. H. & Raistrick, H. (1934). Biochem. J. 28, 828. Birkinshaw, J. H. & Raistrick, H. (1936). Biochem. J. 30, 801. Bir...
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تاریخ انتشار 2005